INS and Hypoglycemia: However, recent studies such as the meta-analysis from randomized control studies [37], and retrospective cohort study from a nationwide U.S. insurance claims from 110, 879 women with GDM [38] showed that, the risks of neonatal hypoglycemia, high fetal birth weight, and macrosomia were higher in women with glyburide compared to insulin, although glyburide is as effective as insulin [37, 38].