However, in model 3, which included HOMA-IR (fasting glucose was removed from the model due to collinearity), HbA1c remained statistically significantly associated with betatrophin levels (STD β = 0.300, P = 0.005), whereas the association between NAFLD and betatrophin levels was diminished in this model. This evidence concerns the gene ANGPTL8 and metabolic dysfunction-associated steatotic liver disease.