Changes in myelin abundance have been reported in many neuropsychiatric disorders, and links to behavioural outcomes of these disorders have been established in animal models.33 For example, large genome-wide analyses of the PFC of schizophrenic patients have remarkably highlighted abnormal regulation of genes related to myelination.48, 53 Most of these studies report reduced myelin gene expression and white matter volume, with neuroregulin 1 (NRG1), a schizophrenia susceptibility gene,54, 55 expression increased. Here, NRG1 is linked to schizophrenia.