FKBP5 and Borderline personality disorder: In patients with borderline personality disorder, initially increased BDNF gene methylation decreased during a 4-week course of intensive dialectical behavior therapy along with therapy response.32 Finally, Yehuda et al.33 reported FKBP5 methylation to decrease in association with responder status after a 12-week psychotherapy in combat veterans with post-traumatic stress disorder.