PGP and cancer: In concordance with our study, a very recent study has also reported that the triple (Taxol, platinum, 5-fluorouracil) drug-resistance, mediated through P-gp (MDR-1), MRP-2 and survivin, is coupled with the acquisition of cancer stem cell behaviour in association with induced EMT in head and neck cancer and they suggested that acquired drug-resistance is probably achieved by induction of these molecules through multiple EMT and CSC-mediated pathways and showed significant correlation with the prognostic outcome of the patient24.