In this case, we found that our in vivo findings were consistent with our in vitro findings and treatment of animals harboring HUNK knockdown tumors with SP600125 significantly impaired tumor growth measured by volume (S2B Fig) and delayed median time for the tumors to reach a volume of ~600 mm3 by 10.3 days beyond that of SP699125 treatment in animals injected with control cells (Fig 5C). Here, HUNK is linked to neoplasm.