APOE and atherosclerosis: For insight into mechanisms for Sirt6 heterozygosity exacerbated atherosclerosis, we investigated blood pressure (Supplementary Table 1), serum glucose and lipid level (Supplementary Table 2) and body weight (Supplementary Fig. 3) in ApoE−/− mice and Sirt6+/−ApoE−/− mice, which were fed with Western diet for 16 weeks.