Some ligands, including H60b, Rae-1δ, Rae-1ε, are associated with exacerbated atherosclerosis and are reported to be increased in atherosclerotic plaques in ApoE−/− C56BL/6 mice fed with diet containing 35.5% fat for 8 to 9 weeks17. The gene discussed is APOE; the disease is atherosclerosis.