An example of a prospective infectious diagnosis with the subsequent development of CFS/ME was established in a small community in Australia [47] using IgM to IgG seroconversion or rising IgG titers to Epstein-Barr virus (a DNA virus), Ross River virus (an alpha RNA virus), and Coxiella burnetii (an obligate intracellular bacterium and the causative agent of Q fever). Here, CD40LG is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.