Interestingly, the ID genes, which are significantly implicated in the outcome of our patients, have been reported in other models of cancer as promoters of cell survival and have been associated with the up-regulation of anti-apoptotic pro-survival factors through activation of NF-kB signaling pathway [43], which represents the signaling pathway most aberrantly regulated in the non-response group (Fig. 1c). Here, NFKB1 is linked to cancer.