Other genes showing altered expression in the poor response group included CENTG2 (AGAP1), RPS4Y1 and RGS1. Interestingly, CENTG2 has been reported to have dual roles in susceptibility to disease due to its association with a bad prognostic signature in B-ALL in children [32], but having a protective role in gastric cancer [57]. The gene discussed is RGS1; the disease is acute lymphoblastic leukemia.