In the absence of data on the diagnostic euglycemic clamp, we used six previously established measures of IR [12]: fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostatic model of assessment – insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI) [13], McAuley index [14] and leptin/adiponectin ratio [15]. The gene discussed is LEP; the disease is Insulin resistance.