The hypomethylation status of STK31 was significantly associated with HPV16/18 infection, chemotherapy treatment and chemotherapy resistance (p < 0.05) and was not associated with age, the type of cancer, lymph node metastasis, cancer grade, the FIGO stage, tumor size, HPV genotyping or Squamous cell carcinoma antigen (SCC-Ag) level (p > 0.05; Table 1). This evidence concerns the gene STK31 and metastatic malignant neoplasm in the lymph nodes.