In an animal model of glomerulonephritis that is induced by injection of anti-thymocyte serum in rats Okuda et al. showed that increased TGFβ1 expression was coupled to increased production of proteoglycans and glomerular matrix accumulation [31] and involvement in IgAN has been suggested by us and others [32, 33]. Here, TGFB1 is linked to glomerulonephritis.