GUCY2C and irritable bowel syndrome: GC-C signaling has also been implicated in the regulation of satiety (Valentino et al. 2011), irritable bowel syndrome (IBS) and abdominal pain (Castro et al. 2013; Chey et al. 2012), tumor growth (Lin et al. 2010; Wilson et al. 2014) and the maintenance of intestinal barrier function (Han et al. 2011).