NOS2 and ischemic stroke: Recent experimental data from a murine model of ischemic stroke demonstrate that prophylactic statin therapy augments cerebral blood flow, reduces infarct size by 30%, and improves neurological outcome in normocholesterolemic animals.43 Statins have been shown to reduce infarct size in experimental animal models of stroke by means a summa of neuroprotective action such as upergulation of endothelia eNOS and inhibition of inducible inducible nitric oxide synthase (iNOS), lowering neuronal inflammation and amelioration of ischemic oxidative stress in brain.