Recent experimental data from a murine model of ischemic stroke demonstrate that prophylactic statin therapy augments cerebral blood flow, reduces infarct size by 30%, and improves neurological outcome in normocholesterolemic animals.43 Statins have been shown to reduce infarct size in experimental animal models of stroke by means a summa of neuroprotective action such as upergulation of endothelia eNOS and inhibition of inducible inducible nitric oxide synthase (iNOS), lowering neuronal inflammation and amelioration of ischemic oxidative stress in brain. The gene discussed is NOS3; the disease is ischemic stroke.