PON1 and diabetes mellitus: Oxidative stress and mild chronic vascular inflammation also play a role in the pathophysiology of hypertension and atherosclerosis.1 In the literature, many studies reported that the increased oxidized low-density lipoprotein (LDL) in type 2 diabetes mellitus is correlated with an increased risk of cardiovascular complications.2 This increased susceptibility of LDL to oxidation is dependent on the antioxidant capacity of high-density lipoprotein (HDL)-associated paraoxonase-1 (PON-1).