In agreement, our ChIP assays showed that DNMT1/3a/3b and the transcriptional repressive histone mark H3K27me3 are recruited to the promoter region of FOXO3 in BRCA1-low and -mutated breast cancer cell lines but not in BRCA1-competent MCF-7 cells. The gene discussed is BRCA1; the disease is breast carcinoma.