FOXO3 and breast cancer: In concordance, analysis of FOXO3 and EZH2 transcript levels in a previously published breast cancer cohort (3554 breast cancer patients)28 revealed that low FOXO3 and high EZH2 mRNA expression levels are very significantly associated with poor survival (P<0.033 and P=3.8 × 10−11, respectively, for overall survival, Kaplan–Meier analysis (Figure 10b).