It has been shown that aberrant expression of specific T-UCRs is associated with chronic lymphocytic leukemia, colorectal cancer and hepatocellular carcinoma.16, 18, 19 We previously reported that Hu antigen R regulated alternative splicing of TRA2β to selectively produce TRA2β4 in human colon cancer cells under oxidative stress.27 Although TRA2β4 is a PTC variant, transcribed TRA2β4 was retained preferentially within the nucleus and resistant to the RNA surveillance NMD. Here, TRA2B is linked to malignant colon neoplasm.