Tra2β is overexpressed in several types of cancers and has been suggested to participate in their abnormal growth.2, 8 In fact, our previous studies showed that Tra2β knockdown inhibited proliferation of colon cancer cells and induced their apoptotic cell death.9, 10 In the present study, we found that TRA2β4 (rather than Tra2β-encoding TRA2β1) was consistently overexpressed in all colon cancer cell lines tested. The gene discussed is TRA2B; the disease is cancer.