An SR-like protein transformer 2β (Tra2β) regulates splice site selection of several genes encoding calcitonin/calcitonin gene-related peptide (CGRP), survival motor neuron 1 (SMN1) and microtubule-associated protein tau (TAU) in a concentration-dependent manner.5, 6, 7 Several lines of evidence suggest that overexpressed Tra2β may be involved in the pathogenesis of cancer.8, 9, 10 The human TRA2β (TRA2B) gene is composed of 10 exons and 9 introns. This evidence concerns the gene CALCA and cancer.