Further, the aberrant serum levels of miRNAs in the panel, namely miR-21 (high), miR-126 (low), miR-155 (high), miR-199a (low) and miR-335 (low), could identify breast cancer with hormone-negative receptor status [46], in which the three common hormone receptors are not present in cancer tissues, so they are also called triple negative breast cancer. This evidence concerns the gene NR4A1 and cancer.