In another study by Rheinbay and colleagues [151], an epigenomic analysis comparing chromatin landscapes of GBM CSCs to human astrocytes, identified Achaete-Scute Complex-like 1 (ASCL1) as an important activator of Wnt signaling from a list of aberrantly expressed genes normally kept inactive by Polycomb receptors. The gene discussed is ASCL1; the disease is glioblastoma.