Our detailed genotype-phenotype analysis indicated that without Bonferroni correction: (i) the RORc2 rs9826 A/G polymorphisms under recessive model ((AA + AG) vs. GG) was associated with the disease duration of RA, median value of CRP, VAS score, and creatinine level; (ii) the rs12045886 T variant was associated with a significantly higher median value of PLT and lower number of women; and (iii) the carriers of the combined rs9017 GA + AA genotype were a higher median value of CRP, VAS, HAQ and DSA-28 score. This evidence concerns the gene CRP and rheumatoid arthritis.