Previous studies show that the mechanisms of palmitic acid induced cell damages mainly involve insulin resistance [22], endoplasmic reticulum stress (ERS) [23], oxidative stress [24], apoptosis [25,26,27,28,29], autophagy [30], and production of many pro-inflammatory factors [31,32] to cause endothelial dysfunction and cardiovascular diseases. The gene discussed is INS; the disease is endothelial dysfunction.