In relation to gut health, the optimal inhibition of DPP-IV may aid in remediation of non-steroidal anti-inflammatory drug-induced intestinal ulcers [42], by possibly enhancing the beneficial amino acid- and bile acid-induced bicarbonate secretion in the small intestine [43], besides promoting epithelial regrowth [18] and stimulating intestinal growth [44]. Here, DPP4 is linked to intestinal disorder.