For example, baicalin and rosmarinic acid (active ingredients of composite formulas of TCM, Yang–Gan–Wan), prevent methyl-CpG binding protein 2—enhancer of zeste homolog 2 (MeCP2-EZH2) relay, hence prohibiting hepatic fibrosis via allowing re-expression of PPAR-c [230]. Here, EZH2 is linked to Hepatic fibrosis.