RUNX3 and colonic neoplasm: Besides, the elevation of methylation of RUNX3 (runt-related transcription factor 3) in cells exposed to H2O2 [86], which is an epigenetic mechanism controlling SOD2 transcriptional activity throughout the pathogenesis of human cancers [87], and upregulation of DNMT1 in colon cancer-derived cell lines [88], result in H2O2-mediated epigenetic modifications.