In the present study, we determined an inverse association between serum APOA1-UP level and the acute onset of ischemic stroke and found that a decrease in the serum APOA1-UP/LRP ratio was related to an increase in the positive rate of acute ischemic stroke, adjusting for age, DM, hypertension, and previous IHD. The gene discussed is APOA1; the disease is hypertensive disorder.