C3 and cancer: Among the 71 novel cancer driver genes reported by Porta-Pardo et al. [2] only 10 of them (GLUL, A2M, CYP2B6, CSNK1E, SLIT2, C3, SERPINB3, HLA-DRB1, SEC13 and TLR4) are present in our set of positively selected 557 interactions (only C3 and HLA-DRB1 if we exclude homodimer-oligomerization interactions).