Lindahl [20] in the elegant review stress the role of GDF-15 as new piece in the puzzle in the world of biomarkers as it has been associated with increased cardiovascular as well as non-cardiovascular mortality, and development and progression of a broad range of diseases, such as coronary artery disease, heart failure, diabetes, cancer, and even cognitive impairment. This evidence concerns the gene GDF15 and Cognitive impairment.