Our pathway analysis using Diana Tools showed that miR-196a2 target molecules essential for the regulation of both calcium signaling and actin cytoskeleton pathways (PDGFRA, ROCK1, OCRL (oculocerebrorenal syndrome of Lowe) and DIAPH2 (diaphanous homolog 2 genes), which in turn modulate downstream effectors essential for long-term potential, actin polymerization, actinomyosin assembly contraction, and phosphatidylinositol signaling pathway. This evidence concerns the gene ROCK1 and oculocerebrorenal syndrome.