PKN1 and lung adenocarcinoma: We also determined that although, in NHLF, another gene PKN1 (member of the protein kinase C superfamily) carried the dual histone modifications in the promoter region, differences were observed in the location of the H3K27ac histone modifications compared to those highly shared among the lung adenocarcinoma cell lines (Fig 2(B)-A (lung adenocarcinoma) compared to B (NHLF)).