HIF-1α signaling pathway is frequently observed in solid tumors and is strongly associated with numerous pathophysiological processes, including the induction of epithelial-mesenchymal transition (EMT), a process in which epithelial cells lose cell-cell adhesion and cell polarity and acquire properties of mesenchymal cells, which results in cancer progression, metastasis, and multidrug resistance in cancer [32–35]. Here, HIF1A is linked to cancer.