It turned out that C-K treatment can significantly increase the percentages of early and late apoptotic MDSCs in vitro, decrease the expressions of immunosuppression-related genes Cox-2 and Arg-1, and suppress the function of IL-1β, IL-6, and IL-17, which implied that C-K can restrain the immunosuppressive effect of MDSCs to inhibit tumor cell proliferation in mice [47]. Here, ARG1 is linked to neoplasm.