Li et al. explored the effect of Invigorating Spleen and Detoxification Decoction (ISD) (Radix Codonopsis, Poria, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Bupleuri, Rhizoma Curcumae, and herba Scutellaria barbata) on MHC molecules in the rat liver cancer tissue and found that ISD could enhance the expression of MHC I and MHC II both in tumor and in liver tissue, besides prolonging the survival time and decreasing the incidence of cachexia [119]. Here, HLA-C is linked to neoplasm.