VEGFA and neoplasm: A study showed that NCTD inhibited tumor growth and lymphangiogenesis of HCACs through “multipoints priming” mechanisms, that is, directly or indirectly downregulating VEGF-A, -C, -D/VEGFR-2, -3 signaling pathways, which strongly suggested that NCTD could serve as a potential antilymphangiogenic agent for tumor lymphangiogenesis [82].