Since cancer stem cells (CSCs) are involved in the aggressive behavior of tumor, ubiquitin-specific protease 44 (USP44) positive CSCs subclones under inflammatory environment showed increased levels of IL6 and IL8 (ALDH1+/USP44+/IL-6+/IL-8+) that may contribute to the prediction of VM formation and invasiveness of tumor [26]. The gene discussed is CXCL8; the disease is cancer.