IGHE and kidney failure: Dizbay et al. [12] determined hypocomplementemia, increased levels of polyclonal immunoglobulins (IgG, IgA, and IgE), positivity of rheumatoid factor and P-ANCA in the patients with renal failure, and leukocytoclastic vasculitis due to brucellosis and the authors stated that they thought that this picture was caused by mixed cryoglobulinemia.