Dizbay et al. [12] determined hypocomplementemia, increased levels of polyclonal immunoglobulins (IgG, IgA, and IgE), positivity of rheumatoid factor and P-ANCA in the patients with renal failure, and leukocytoclastic vasculitis due to brucellosis and the authors stated that they thought that this picture was caused by mixed cryoglobulinemia. The gene discussed is IGHE; the disease is Renal insufficiency.