BST‐2‐mediated activation of NF‐κB 14, 15, 16, 17 may result in the induction of several factors involved in cancer cell migration and invasion including matrix metalloproteases, chemokines, or growth factors (Fig. 3, Box 2), as well as in intravasation of tumor cells (Fig. 3, Box 3), and resistance to anoikis 133, 134 (Fig. 3, Box 4). The gene discussed is NFKB1; the disease is cancer.