VEGFA ligand binding to VEGFRs upregulates expression of endothelial nitric oxide synthase (eNOS) and increases prostacyclin production in endothelial cells [4], and is strongly expressed in antiproliferative lesions from patients with severe primary idiopathic and secondary forms of pulmonary hypertension [5, 6]. The gene discussed is NOS3; the disease is pulmonary arterial hypertension.