The total mutation loads were significantly higher in the group of cancers with the lower NEIL1 and NEIL2 expression levels in 4 of the 13 (30.8%) cancer types and 2 of the 13 (15.4%) cancer types, respectively (Figure 1(b), Supplementary Figure S4, and Supplementary Tables S4 and S5). This evidence concerns the gene NEIL2 and cancer.