However, Hippo pathway genes are infrequently germline or somatically mutated in human cancers whether in targeted or whole genome sequencing research; this is especially true of the core Hippo pathway genes, example for neurofibromin 2 (NF2; also known as Merlin) in neurofibromatosis and malignant mesothelioma, and LATS2 in malignant mesothelioma. This evidence concerns the gene LATS2 and malignant mesothelioma.