The expression of SIRT1 is significantly upregulated in the HCC samples, and SIRT1 deacetylates YAP2 protein in HCC cells, which increases the YAP2/TEAD4 association, leading to YAP2/TEAD4 transcriptional activation and upregulated cell growth in HCC cells [43]. The gene discussed is SIRT1; the disease is hepatocellular carcinoma.