ADRB2 and neoplasm: In order to contribute with recent studies and investigate the role of β2-AR in OSCC, the present study aimed to analyze the expression of β2-AR in the tumor-free surgical margin and at the invasive front of a large sample of OSCC to verify if β2-AR expression is correlated with tumor-free surgical margins and the invasive front of OSCCs and to explore associations between β2-AR expression levels and clinicopathological features.