Concerning OSCC, similarly to normal epithelium, the invasive front of tumor is considered as the most progressed region by Piffkò et al. [29], and approximately three to six tumor cell layers or detached tumor cell groups were positively immunostained for β2-AR at the cytoplasm and plasma membranes of malignant epithelial cells, except for the keratin pearls that were negative (Figure 2). The gene discussed is ADRB2; the disease is neoplasm.