Thus, this study evaluated the participation of circulating and skin IL-22-, IL-17-, IL-4-, and IFN-γ-producing cells, as well as regulatory subsets (Tregs, Bregs, and pDCregs) and serum levels of IL-22, IL-17, and IL-10 in patients with DLE and SCLE and with regard to disease activity. Here, IL22 is linked to discoid lupus erythematosus.