E2F1 and chronic myelogenous leukemia, BCR-ABL1 positive: Agglomerative hierarchical clustering analysis (Fig. 1a), and Ingenuity® Pathway Analysis (IPA, QIAGEN Redwood City, www.qiagen.com/ingenuity) revealed key hubs, including CCND1, PCNA, E2F1, RAD51, FANCD2, and AURKB, representing cell cycle, cancer, and cellular movement associated genes that distinguished CP CML from normal progenitors (Fig. 1b).