Agglomerative hierarchical clustering analysis (Fig. 1a), and Ingenuity® Pathway Analysis (IPA, QIAGEN Redwood City, www.qiagen.com/ingenuity) revealed key hubs, including CCND1, PCNA, E2F1, RAD51, FANCD2, and AURKB, representing cell cycle, cancer, and cellular movement associated genes that distinguished CP CML from normal progenitors (Fig. 1b). Here, FANCD2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.