To provide insights into differences between normal and chronic phase (CP) CML progenitor cell cycle regulation, cell cycle regulatory gene expression changes were quantified using whole transcriptome RNA sequencing (RNA-seq) of fluorescence-activated cell sorting (FACS)-purified CP CML, normal peripheral blood (NP), and cord blood CD34+ CD38+ Lin− progenitors. The gene discussed is CD38; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.