Agglomerative hierarchical clustering analysis (Fig. 1a), and Ingenuity® Pathway Analysis (IPA, QIAGEN Redwood City, www.qiagen.com/ingenuity) revealed key hubs, including CCND1, PCNA, E2F1, RAD51, FANCD2, and AURKB, representing cell cycle, cancer, and cellular movement associated genes that distinguished CP CML from normal progenitors (Fig. 1b). This evidence concerns the gene FANCD2 and cancer.