SREBF1 and hydrops fetalis: Both Rev-Erb and RORα may regulate lipid metabolism through the lipogenic transcription factor Srebp1c. Expression of this gene was increased in livers from both the C/HF and HF/HF offspring (Fig. 3j; p < 0.05, C/HF and HF/HF vs C/C), consistent with increased hepatic fat accumulation in these groups.