Although further research in this area is warranted to fully understand the multifaceted nature of developmentally primed liver disease, our mechanistic insights suggest that supplementation with factors able to reverse the effects of depleted NAD+ reserves, and/or SIRT1 and SIRT3 abundance may also have the potential to alleviate the effects of developmental HF exposure, and rescue the increased susceptibility to develop severe fatty liver disease in later life. Here, SIRT3 is linked to fatty liver disease.