The clonal diversity of the peripheral blood CD8+ TCR repertoire from 23 RE patients including 6 adult-onset cases and age- and sex-matched children suffering from temporal lobe epilepsy (TLE; n=4), cortical dysplasia (CD; n=4), headache (n=8) and common cold (n=5) were assessed by high-throughput sequencing. Here, CD8A is linked to Cowden disease.