Even though mir-101 is down-regulated in many cancer forms, the up- or down-regulation of mir-101 is not obvious in EAC, both as it is a part of the TrkB-STAT3 regulatory response, where mir-101 gets up-regulated by increased TrkB levels, and TrkB protein levels is increased in many endometrial carcinoma samples [30]. This evidence concerns the gene STAT3 and cancer.