The SCN8A gene encodes a protein that is important for neuron hyperexcitability [47] and mutations in this gene are known to cause cerebellar ataxia, which is the similar to that of ITPR1. Given the importance of 3p region in neurological disorders and potential role of uric acid as biomarker for these disorders, this region assumes significance. The gene discussed is SCN8A; the disease is cerebellar ataxia.