NR3C1 and experimental autoimmune encephalomyelitis: Of note, studies in the animal model of experimental autoimmune encephalomyelitis have demonstrated that the density of membrane-bound glucocorticoid receptors (GCRs) on T cells is critical for apoptosis induction, and T cells with a higher density of GCR expression are more susceptible to glucocorticoid-mediated apoptosis compared to those with a lower density of GCR expression [52].