SHH and gastric cancer: Furthermore, as shown in Table 1, a chi-square test suggested that high SHH expression (scores of 2+ and 3+) in GC tissue samples significantly correlated with advanced distant metastasis (pM staging, 20.8 % vs 4.3 %, P = 0.006), and advanced TNM staging (89.6 % vs 55.1 %, P < 0.001).