SHH and gastric cancer: As shown in Table 2, a univariate analysis showed that gender (HR = 0.580, 95 % CI, 0.360–0.934, P = 0.025), age (HR = 1.682, 95 % CI, 1.071–2.641, P = 0.024), differentiation degree (HR = 0.623, 95 % CI, 0.389–0.997, P = 0.049), pN staging (HR = 1.652, 95 % CI, 1.221–2.234, P = 0.001), pM staging (HR = 3.017, 95 % CI, 1.536–5.926, P = 0.001), and SHH expression (HR = 1.776, 95 % CI, 1.119–2.820, P = 0.015) were significantly associated with GC prognosis.