INS and Hyperglycemia: Based on the results of mechanistic studies in healthy volunteers, a panel of experts have recently recommended that hyperglycemia associated with pasireotide in patients with Cushing’s disease should be managed by the following staged intensification of antidiabetic treatment until glycemic control is achieved: (i) initiation of metformin; (ii) addition of a DPP-4 inhibitor; (iii) switch from the DPP-4 inhibitor to a glucagon-like peptide 1 receptor agonist; (iv) initiation of insulin therapy [23].