APOC3 and coronary artery disorder: For example, loss-of-function mutations in apolipoprotein C3 (APOC3), which is an inhibitor of LPL, decrease the risk of coronary artery disease (CAD) [7], while loss-of-function mutations in apolipoprotein A5 (APOA5), which is an activator of LPL, increases the risk of CAD [8].