We have demonstrated previously that acquired Hsp27 activation by p38 MAPK/MAPKAPK2/Hsp27 signaling cascade confers apoptosis-resistance to t-AUCB treatment in glioblastoma cells, although the cell proliferation inhibition and cell cycle G1 phase arrest induced by t-AUCB were significant [15]. The gene discussed is MAPKAPK2; the disease is glioblastoma.