PTGS2 and glioblastoma: Our study demonstrates that t-AUCB inhibits cell proliferation, migration and invasion and induces cell cycle G1 phase arrest in vitro; increased Hsp27 activation and following COX-2 overexpression confer resistance to t-AUCB treatment in glioblastoma in vitro and in vivo; quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2.