Zhang et al. recently demonstrated that high-dose t-AUCB (10 mg · kg−1 · d−1) increases primary tumor growth and metastasis by stimulating tumor angiogenesis and VEGF levels, whereas low dose t-AUCB, 1 mg · kg−1 · d−1 or 3 mg · kg−1 · d−1, inhibits Lewis lung carcinoma metastasis or has no effect on primary tumor growth and metastasis, which makes the effects of t-AUCB on tumors more and more complicated [16]. Here, VEGFA is linked to neoplasm.