Concurrent seropositivity for anti-carbVIM IgM, anti-carbMCV IgM, anti-MCV IgG, RF IgM and anti-CCP2 was detectable in 12.0 % of samples from patients with early RA and in 30.0 % of patients with established RA (Table 2). This evidence concerns the gene AGBL2 and rheumatoid arthritis.