Furthermore for ATII-induced hypertension, it has been reported that the β1, but not the pore-forming alpha subunit, is downregulated, which mediates a decrease in the sensitivity of BK channels and thereby contributes to vascular dysfunction (Amberg et al., 2003; Nieves-Cintron et al., 2007). Here, KCNMA1 is linked to Hypertension.