Because PKG-induced phosphorylation of LZ+ MYPT1 isoforms and subsequent activation of the MLC phosphatase (Yuen et al., 2011; Yuen et al., 2014) is a key component in the NO/cGMP signaling pathway leading to vasodilatation (Lincoln, 1989), increasing MYPT1 LZ+ expression should be effective for both for reversing nitrate tolerance and the treatment of essential hypertension. The gene discussed is PPP1R12A; the disease is hypertensive disorder.