During heart failure (HF), p42/44 MAP kinase is activated and the expression of LZ+ MYPT1 decreases (Ararat and Brozovich, 2009), and further losartan therapy prevents the activation of p42/44 MAP kinase and preserves LZ+ MYPT1 expression (Ararat and Brozovich, 2009). This evidence concerns the gene PPP1R12A and heart failure.