ANO1 and hypertensive disorder: Indeed, downregulation or inhibition of TMEM16A led to decreased arterial constriction in a variety of studies (Jensen and Skott, 1996; Bulley et al., 2012; Davis et al., 2013; Dam et al., 2014), and a smooth muscle KO of TMEM16A in mice lead to a decrease in the ability of ATII infusion to produce hypertension.