AGT and Hypertension: A similar effect was obtained with the newer ROCK inhibitors fasudil, SAR07899, in other animal models of hypertension, including the spontaneously hypertensive rat (SHR), angiotensin II-induced hypertension in several animals, and L-NG-Nitroarginine Methyl Ester (L-NAME)-induced hypertension (Uehata et al., 1997; Mukai et al., 2001; Kumai et al., 2007; Lohn et al., 2009).