CDH3 and hypotrichosis: Interestingly, Basit et al. [34] described a digenic mode of inheritance for hypotrichosis in two independent human families with one locus represented by mutations in the cadherin 3 (CDH3) gene and a second locus located in a chromosomal region (HSA12q21.2-22) that is syntenic with a region on BTA5 around 18 Mb.